As Americans in today’s society expectations of complete trust and safety are given to doctors when prescriptions are written after a diagnoses. Many never hesitate to ask why they prescribe this new prescription and only hope the judgment in the health decisions will be for the better.
As a woman entering motherhood our hopes and dreams for a healthy baby are conscience on our mind; questioning everything put in our bodies only to ensure the unborn baby is equipped with the best start possible. The OBGYN becomes the best friend and closest confidant during pregnancies. When an expecting mother is forced to take a medication due to the possibilities of preterm labor and the risks outweigh the side effects of the drug, that woman trusts her doctor and hopes only for the best.
Most OBGYNs diagnose preterm labor with a tocolitic medication; Tocolytics are medicines that attempt to stop labor. They are used if labor begins before term.
Tocolytics can stop labor or delay labor to give the baby’s lungs time to mature. When taking this medication, you may need hospitalization or home therapy. Even more worrisome than giving birth pre-term are the risks tocolitics may cause.
Terbutaline, also known as Brethaire, Brethine, and Bricanyl is often used as a tocolitic remedy. Terbutaline sulfate Brethine is said to be generally safe for women who are pregnant. In previous animal studies involving terbutaline and pregnancy, the drug did not cause any problems. Making this drug a category B classification by the FDA regulation. Pregnancy Category B is given to medicines that have not been studied in pregnant humans but do not appear to cause harm to the fetus in animal studies. Yet, maternal deaths have occurred due to terbutaline use during pregnancies.
Some of the side effects include nervousness, restlessness, insomnia, headache, rapid heart rate, nausea, hyperglycemia (high blood sugar) and hypokalemia (low blood potassium). A rare but serious side effect is pulmonary edema. The side effects are identical in the mother and unborn born baby because the drug crosses the placenta. The mother and baby should be monitored while taking this drug.
In one review of 8,709 patients only 47 had one or more cardiopulmonary problems. Pulmonary edema was reported in 28 patients, 17 of whom had been treated concurrently with large amounts of IV fluids or tocolytic agents and four of whom had been diagnosed with pregnancy-induced hypertension and preterm labor symptoms.
Other cardiovascular effects occurred in 19 patients, including electrocardiogram changes, irregular heart rate, chest pain, or shortness of breathe.
Duke University studied the risks of terbutaline in infants; they found an increased risk of brain damage and cognitive deficits in babies whose mothers were treated with terbutaline during preterm labor. The study showed that the use of terbutaline might predispose babies to autism and other toxins.
Proving the drug caused autism creates debate but fraternal twins may scientifically prove this concept. Fraternal twins are two separate eggs fertilized by two separate sperm to form two separate embryos and then make two separate babies.
Fraternal twins are no more genetically alike than other siblings in the family. Finding fraternal twin pairs in whom both twins have autism spectrum disorders is the key finding that puts a spotlight on the use of terbutaline during pregnancy.
How can the FDA classify this drug as a category B when statistically deaths and birth defects clearly correlate with the use of this medication? How can the FDA warn doctors of the side effects but allow them to prescribe this medication as an off-label remedy. Furthermore, why do doctors continually prescribe this medication to expecting mothers knowing the risks that may occur?
As a woman expecting prayer and hope for perfect health is a daily process.
Expertise and trust within the doctor help suppress any negative thoughts but at the end of the day reality proves each patient is simply another number.